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Common drugs may lead to greater cures

... Joplin Independent:Common drugs may lead to greater cures Today is: Sun, Apr 29, 2007 HomeBusinessCalendar of EventsClassifiedsCommunityEditorialEducationEntertainmentFeaturesGlobalGovernmentHealthHome and GardenHumorKidz KornerMiscellaneousLetters to the EditorOp-EdPeoplePhoto GallerySound BitesSportsTravel & Leisure About UsContact UsRegisterLoginForumLinksSubmit News Site Design by: Home-Common drugs may lead to greater cures Common drugs may lead to greater curesby: jhu-psUpdated: 2007-04-29 12:58:22-05Researchers at Johns Hopkins have discovered to their surprise that two drugs commonly used for treatment might be beneficial in treating other more serious disorders.

These researchers discovered that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers.

The drug, itraconazole, already is FDA approved for human use, which may fast-track its availability as an antiangiogenesis drug.

In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67 percent compared to placebo.

"We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Jun O.

Liu, Ph.D., professor of pharmacology.

"We couldn't have predicted that an antifungal drug would have such a role." In their search for antiangiogenesis drugs, the researchers worked with cells from human umbi...

Governor Spitzer To Propose Healthy Lunch Legislation For Schools

...The bill would also limit beverages to water, milk and juice, and would require all schools to participate in a breakfast program.

State legislators will need to vote on the proposal.

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Correlation between bile duct obstruction and ductal cancer found

...Bile duct obstruction has long been known to be present in both malignant and nonmalignant liver disease (jaundice, for example), but before the study by Dr.

Sirica and his colleagues the direct effect of such obstruction on bile duct cancer cell growth and aggressiveness had not been previously investigated.

These new findings are highly significant for two reasons, says Dr.

Sirica.

First, they establish an important correlation between bile duct obstruction and bile duct cancer, suggesting growth regulatory mechanisms that could be highly significant in the progression of the cancer and that could become good molecular targets for drug therapy.

Second, they establish a unique preclinical model of how bile duct cancer in liver progresses that can be used to rapidly test and evaluate novel molecular treatment strategies.

Such strategies are badly needed for this understudied cancer, adds Dr.

Sirica.

The incidence and mortality of cholangiocarcinoma, the primary cancer of the bile ducts, is increasing worldwide.

Some 3,500 new cases are now diagnosed annually in the United States.

Survival rates remain dismally low because most patients have advanced disease at the time of diagnosis and thus are poor candidates for the current best treatment, surgical resection.

Although there are some known risk factors for the disease (such as primary sclerosing cholangitis), the cause of...

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